Lupus & antiphospholipid syndrome
Pregnancy outcomes in patients receiving assisted reproductive therapy with systemic lupus erythematosus: a multi-center retrospective study
An erratum to this article was published (Arthritis Res Ther, 7 Feb 2023 ↗)
Authors' conclusion
Maternal and fetal APOs are comparable with planned pregnancy, with a relatively high incidence of premature delivery, GDM, and LBW infants.
Study context
- Population
- Women with systemic lupus erythematosus (SLE) receiving assisted reproductive therapy (ART) at three tertiary hospitals, Guangzhou, China, 2013–2022322 ART cycles
- Participants
- 142 women
- Exposure
- ART pregnancies vs planned or unplanned natural pregnancy
- Outcome
- Clinical pregnancy rate
Methodological detailsmulticentre, three tertiary hospitals
- Multicentre
- Three tertiary hospitals
Main finding
As reported in the abstract
Clinical pregnancy rate with ART (66/142)
46.5%
Observational data: associations, not effects.
Further findings
Live infants
- Live infants from 66 intrauterine pregnancies (of 72 clinical pregnancies), including 5 pairs of twins
- 65
Premature delivery (leading maternal APO)
- Premature delivery (21/66)
- 31.8%
- Spontaneous premature delivery among premature deliveries (9/21)
- 42.9%
- Preterm premature rupture of membranes (PPROM) among premature deliveries (6/21)
- 28.6%
- Preeclampsia, premature vs non-premature delivery (P = 0.012)
- 19.0% vs 0%
- Low-birth-weight (LBW)/very-low-birth-weight (VLBW), premature vs non-premature infants (P < 0.001)
- 81.0% vs 7.7%
Gestational diabetes mellitus
- Gestational diabetes mellitus (GDM) (15/66)
- 22.7%
Delivery time and birth weight
- Average delivery time, weeks of gestation
- 36.8 ± 2.1
- Average birth weight, g
- 2653.5 ± 578.6
- LBW infants (20/65)
- 30.8%
Adverse pregnancy outcomes (APOs), ART vs planned and unplanned natural pregnancy
- Incidence of APOs did not increase with ART vs planned pregnancy and reduced significantly vs unplanned pregnancy
Neonatal death or neonatal lupus
- No neonatal death or neonatal lupus
Safety
Ovarian hyperstimulation syndrome (OHSS) or thrombosis with ovulation induction therapy (60 [83.3%] pregnancies)
- No OHSS or thrombosis observed
Disease flares
- Disease flares (10/66)
- 15.2%
- Mild flares (4/10)
- 40.0%
- Moderate flares (5/10)
- 50.0%
- Flares in second trimester (3/10)
- 30.0%
- Flares in third trimester (6/10)
- 60.0%
- Favorable outcomes
Fetal loss
- Fetal loss in ART (6/66)
- 9.1%
- Early spontaneous abortion
- 5
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →