Moderate and high disease activity levels increase the risk of subclinical atherosclerosis progression in early rheumatoid arthritis: a 5-year prospective study
Main finding · AP+ at year 5Result — go to the resultOdds ratio 5.05 95% CI 1.53–16.64Authors' conclusion
Achieving persistent LDA or remission may prevent progression of atherosclerosis in ERA.
Study context
- Population
- Consecutive patients with early RA without overt cardiovascular disease (CVD); 1 year of tight-control treatment then standard-of-care management (age 52±11 years; 77.9% female)81 (77.9%) female
- Participants
- 104 patients
- Exposure
- Persistent moderate or high disease activity vs persistent remission
- Outcome
- Subclinical atherosclerosis progression (AP+): incident plaque, increased region harbouring plaques and/or maximum carotid intima-media thickness progression ≥0.9 mm on high-resolution carotid US
- Follow-up
- Year 5
Methodological details5-year follow-up, multivariate logistic regression
- 5-year follow-up
- Multivariate logistic regression
Main finding
AP+ at year 5
Odds ratio
5.05
95% CI 1.53–16.64
P = 0.008
Persistent moderate or high disease activityvs Persistent remission
OR 5.05 (95% CI 1.53–16.64); P = 0.008
As reported in the abstract
Observational data: associations, not effects.
Further findings
Overall AP+ and persistent low disease activity (LDA) or remission (whole cohort) · year 5
- Patients with AP+
- 42 (40.4%)
- Patients achieving persistent LDA or remission
- 52 (50%)
- AP+ patients were older and had more traditional cardiovascular risk factors at baseline
Original publication
Moderate and high disease activity levels increase the risk of subclinical atherosclerosis progression in early rheumatoid arthritis: a 5-year prospective study. RMD Open. Published 10 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →