Synovial tissue features associated with poor prognosis in inflammatory arthritis
Authors' conclusion
The presence of LN + and higher CD15 + polymorphonuclear cells infiltrate was associated with PPF in RA and PsA, respectively. No associations were found for UA.
Study context
- Population
- Patients with active arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), undifferentiated arthritis (UA)) with synovial tissue obtained by rheumatological arthroscopy or US-guided biopsy; patients on biological therapy at biopsy excludedfollowed up 5 years
- Participants
- 88 patients
- Exposure
- RA vs PsA vs UA
- RAn = 26
- PsAn = 33
- UAn = 29
- Outcome
- Association of synovial tissue inflammatory cell infiltrate and ectopic lymphoid neogenesis (LN +) with poor prognosis factors (PPF)
Main finding
As reported in the abstract
5 years after biopsy
- RA: LN + associated with poor prognosis factors (PPF)
- p 0.038
- RA: LN + associated with biologic therapy initiation
- p 0.018
- PsA: CD15 infiltrate associated with PPF
- p 0.008
- UA: synovial CD68 + macrophage density negatively correlated with DAS28-CRP
- r = - 0.346, p 0.042
Observational data: associations, not effects.
Further findings
| Outcome | RA | UA |
|---|---|---|
| LN + presence | 65.38% | 44.82% |
- CD15 infiltrate in PsA
- 410.68 · SD 477.63 · cells/mm²
Original publication
Synovial tissue features associated with poor prognosis in inflammatory arthritis. Arthritis Res Ther. Published 10 January 2024. doi:10.
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