Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants
Authors' conclusion
Some hormonal and reproductive factors were associated with a higher risk of RA.
Study context
- Population
- Women from the UK Biobank3,313 incident rheumatoid arthritis (RA)
- Participants
- 223,526 women
- Exposure
- Hormonal and reproductive factors vs reference categories, for RA risk in women
- Outcome
- Incident RA
Methodological detailsCox proportional hazard regression, restricted cubic spline
- Cox proportional hazard regression
- Restricted cubic spline
Main finding
As reported in the abstract
median follow-up 12.39 years
Hazard ratio (95% CI)
Menarche >14 yearsvs Menarche at 13
1.13(1.02–1.26)
Reproductive years <33
1.39(1.21–1.59)
≥4 childrenvs 2 children
1.18(1.04–1.34)
Hysterectomyvs No hysterectomy
1.40(1.25–1.56)
Oophorectomyvs No oophorectomy
1.21(1.08–1.35)
HRT use
1.46(1.35–1.57)
HRT duration
1.02(1.01–1.03)
- Menopause <45 years
- multiple adjusted HR 1.46
Observational data: associations, not effects.
Original publication
Hormonal and reproductive factors in relation to the risk of rheumatoid arthritis in women: a prospective cohort study with 223 526 participants. RMD Open. Published 9 January 2024. doi:10.
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