Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis
Authors' conclusion
These four autoantibodies may be useful in diagnostics and in predicting clinical phenotypes of RA.
Study context
- Population
- Early RA from the Swedish population-based Epidemiological Investigation of RA (EIRA) cohort (screening 80 ACPA-negative and 80 ACPA-positive); 93 early-RA patients from the LURA cohort for high-resolution CT (HRCT) lung abnormalities
- Participants
- 317 / 302 / 372
- Comparison
- ACPA-positive vs ACPA-negative RA vs matched controls
- ACPA-positiven = 317
- ACPA-negativen = 302
- Controlsn = 372reference
- Outcome
- Autoantibodies to non-modified proteins associated with presence/absence of ACPAs in RA
Methodological detailsdiscovery screening and validation, suspension bead array, age- and sex-matched controls, logistic regression
- Discovery screening and validation
- Suspension bead array
- Age- and sex-matched controls
- Logistic regression
Main finding
As reported in the abstract
Autoantibody association with ACPA status
Anti-ANOS1 IgG associated with ACPA-positive status, OR
3.02
95% CI 1.87–4.89
Anti-MURC IgG associated with ACPA-positive status, OR
1.86
95% CI 1.16–2.97
Anti-TSPYL4 IgG associated with being ACPA negative, OR
0.41
95% CI 0.19–0.89
Observational data: associations, not effects.
Further findings
Association with smoking and shared-epitope genes
- Anti-ANOS1 IgG associated with smoking habit, OR
- 2.11 (95% CI 1.22-3.69)
- Anti-MURC IgG associated with MHC class II shared-epitope genes, OR
- 1.95 (95% CI 1.11-3.46)
HRCT-defined lung abnormalities (LURA)
- Anti-MAP2K6 and anti-TSPYL4 IgG correlated negatively with HRCT-defined lung abnormalities
Original publication
Identification of circulating autoantibodies to non-modified proteins associated with ACPA status in early rheumatoid arthritis. Rheumatology (Oxford). Published 9 January 2024. doi:10.
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