Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants
Authors' conclusion
Our findings indicate that genetic overlap between patients with RA and MI is minor. Furthermore, genetic overlap between RA and MI risk factors seem unlikely to provide a major contribution to the increased risk of MI observed in patients with RA.
Study context
- Population
- Swedish patients with rheumatoid arthritis (RA) and controls without RA; Myocardial infarction (MI) genome-wide association study (GWAS) data from a previously published meta-analysis25,826 after quality control
- Participants
- 26,637 patients
- Comparison
- RA vs MI genetic susceptibility
- Outcome
- Genome-wide genetic correlation between RA and MI
Methodological detailsGWAS, linkage disequilibrium score regression, LAVA local genetic correlation
- GWAS
- Linkage disequilibrium score regression
- LAVA local genetic correlation
Main finding
As reported in the abstract
Genome-wide genetic correlation, RA and MI
Genome-wide genetic correlation
0.13
95% CI −0.03 to 0.29
Further findings
Local genetic correlation
- Regions with significant local genetic correlation; none harbored known risk SNPs for either trait
- 6
Seropositive and seronegative RA (stratified)
- Estimates similar in seropositive and seronegative RA
Genetic correlation between RA and MI risk factors
- No statistically significant genetic correlations
Original publication
Minor Genetic Overlap Among Rheumatoid Arthritis, Myocardial Infarction, and Myocardial Infarction Risk Determinants. Arthritis Rheumatol. Published 21 June 2024. doi:10.
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