Rheumatoid arthritis susceptibility genes show pathotype-specific expression in synovial tissue of patients with early treatment-naïve rheumatoid arthritis (RA)
Authors' conclusion
Expression of RA susceptibility genes is not evenly distributed across synovial pathotypes but is strongly biased towards the lympho-myeloid pathotype, indicating that current GWAS signals preferentially capture immune-driven disease mechanisms.
Study context
- Population
- Patients with early treatment-naïve RA (PEAC and Flinders cohorts)PEAC N = 87
- Comparison
- Expression of genome-wide association studies (GWAS)-identified susceptibility genes across synovial pathotypes
Methodological detailssynovial RNA sequencing, pathway enrichment analyses
- Synovial RNA sequencing
- Pathway enrichment analyses
Main finding
As reported in the abstract
- RA susceptibility gene expression in synovial tissue separated patients by pathotype and correlated with markers of disease activity
- RA susceptibility genes significantly enriched among genes upregulated in lympho-myeloid synovium, linked to lymphocyte activation and differentiation pathways
- Osteoarthritis (OA) susceptibility genes upregulated in diffuse-myeloid and fibroid synovium
- Both patterns most pronounced in anticitrullinated protein antibody (ACPA)-positive and directionally consistent in ACPA-negative patients
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Rheumatoid arthritis susceptibility genes show pathotype-specific expression in synovial tissue of patients with early treatment-naïve RA. Ann Rheum Dis. Published 25 July 2026. doi:10.
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