Lupus & antiphospholipid syndrome
Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study
Authors' conclusion
This study suggested that DKI and NODDI metrics can complementarily detect WM abnormalities in non-NPSLE patients and revealed ODI as a more sensitive and specific biomarker than DKI
Study context
- Population
- SLE patients without neuropsychiatric symptoms and matched healthy controls
- Participants
- 49 vs 41
- Exposure
- Non-NPSLE patients vs healthy controls
- Non-NPSLEn = 49
- Healthy controlsn = 41reference
- Outcome
- Group differences in brain WM microstructure on 10 diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) diffusion metrics
Methodological detailsage-, sex-, and education-matched healthy controls, multi-shell diffusion MRI, tract-based spatial statistics (TBSS) and atlas-based region-of-interest (ROI) analyses
- Age-, sex-, and education-matched healthy controls
- Multi-shell diffusion MRI
- TBSS and atlas-based ROI analyses
Main finding
As reported in the abstract
WM microstructure (TBSS and atlas-based ROI analyses)
- TBSS: reduced FA, AD and RK and increased ODI in the white matter (WM) of non-NPSLE patients (family-wise error corrected)
- P < 0.05
Observational data: associations, not effects.
Original publication
Microstructural changes of the white matter in systemic lupus erythematosus patients without neuropsychiatric symptoms: a multi-shell diffusion imaging study. Arthritis Res Ther. Published 28 May 2024. doi:10.
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