Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study
Main finding · OP (IVW)Result — go to the resultOdds ratio 0.859 95% CI 0.774–0.953Authors' conclusion
This study indicated that metformin treatment is significantly associated with a reduction in the risk of OP, fracture and higher LS-BMD, FN-BMD, and eBMD. However, there was no significant association with FA-BMD.
Study context
- Population
- Summary statistics from genome-wide association studies for metformin treatment and bone outcomes
- Comparison
- Genetically proxied metformin treatment and osteoporosis (OP), bone mineral density (BMD) and fracture risk
- Outcome
- Risk of OP
Methodological detailsInverse variance-weighted (IVW) main analysis, sensitivity analyses (Cochran's Q, MR-Egger, leave-one-out, Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO))
- IVW main analysis
- Sensitivity analyses (Cochran's Q, MR-Egger, leave-one-out, MR-PRESSO)
Main finding
OP (IVW)
Odds ratio
0.859
95% CI 0.774–0.953
P = 0.004
Metformin treatment
OR 0.859 (95% CI 0.774–0.953); P = 0.004
As reported in the abstract
Further findings
LS-BMD (IVW)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Metformin treatment | 1.063 (1.023–1.105) | P = 0.002 | |
| 0.512Odds ratio (log scale) |
FN-BMD (IVW)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Metformin treatment | 1.034 (1.000–1.069) | P = 0.049 | |
| 0.512Odds ratio (log scale) |
Estimated heel BMD (eBMD) (IVW)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Metformin treatment | 1.035 (1.023–1.047) | P ≤ 0.001 | |
| 0.512Odds ratio (log scale) |
Fracture (IVW)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Metformin treatment | 0.958 (0.928–0.989) | P = 0.008 | |
| 0.512Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Metformin treatment reduces the incidence of osteoporosis: a two-sample Mendelian randomized study. Osteoporos Int. Published 27 March 2024. doi:10.
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