Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis
Authors' conclusion
This review found clinically important moderate certainty evidence showing that the risk of secondary fragility fracture was lower in the FLS intervention at ≥ 2 years.
Study context
- Population
- Adults aged ≥ 50 years; cohort studies and randomized trials searched January 1st, 2010, to May 31st, 202237 studies
- Comparison
- Fracture liaison service (FLS) intervention vs non-FLS intervention
- Outcome
- Secondary fragility fracture risk
Methodological detailsGRADE certainty assessment, sensitivity analyses, 34 (91.9%) of 37 studies rated low risk of bias
- GRADE certainty assessment
- Sensitivity analyses
- 34 (91.9%) of 37 studies rated low risk of bias
Pooled result
As reported in the abstract
Secondary fragility fracture · 1 year
FLS vs Non-FLSRelative risk (CI)
6 pooled studies; low certainty evidence
0.26(0.13–0.52)
≥ 2 years; 13 pooled studies; moderate certainty evidence
0.68(0.55–0.83)
Original publication
Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis. Osteoporos Int. Published 27 March 2024. doi:10.
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