Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants
Main finding · Incident RAResult — go to the resultHazard ratio 1.22 95% CI 1.14–1.30Authors' conclusion
These findings indicated positive associations between MetS and 4 of its components (WC, TG, HDL-C, and hyperglycemia) and the risk of RA
Study context
- Population
- UK Biobank participants4,901 incident RA cases
- Participants
- 369,065 participants
- Exposure
- Metabolic syndrome (MetS) and its individual components vs their absence
- Outcome
- Incident RA
- Follow-up
- Median 12.04 years
Methodological detailsUK Biobank, multivariable Cox proportional hazards regression, mediation analysis
- UK Biobank
- Multivariable Cox proportional hazards regression
- Mediation analysis
Main finding
As reported in the abstract
Hazard ratio
1.22
95% CI 1.14–1.30
MetSvs No MetS
HR 1.22 (95% CI 1.14–1.30)
Observational data: associations, not effects.
Further findings
Incident RA by MetS component · median follow-up 12.04 years
| HR (95% CI) | ||
|---|---|---|
| Elevated WC | 1.21 (1.12–1.32) | |
| Elevated TG | 1.12 (1.05–1.19) | |
| Reduced HDL-C | 1.31 (1.23–1.39) | |
| Hyperglycemia | 1.15 (1.05–1.25) | |
| 0.512Hazard ratio (log scale) |
- Incident RA by MetS component: 4 of 5 components associated with increased RA risk
Incident RA by number of MetS components
- RA risk increased with number of MetS components; highest with all 5 components
Mediation by C-reactive protein (CRP) of MetS–RA association
- Proportion of total effect mediated by CRP
- 9.27%
Original publication
Metabolic Syndrome Is Associated With an Increased Risk of Rheumatoid Arthritis: A Prospective Cohort Study Including 369,065 Participants. J Rheumatol. Published 15 January 2024. doi:10.
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