High leptin levels in blood are associated with chronic widespread pain in rheumatoid arthritis
Authors' conclusion
This study showed an increased occurrence of CWP in RA-patients with high leptin levels. The association between leptin and CWP remained after adjusting for gender, age and BMI or waist circumference.
Study context
- Population
- Patients with Rheumatoid arthritis (RA) who filled in a questionnaire including a pain mannequin and submitted blood samples to a biobank
- Participants
- 334 patients
- Exposure
- Leptin levels in blood in RA patients with vs without chronic widespread pain (CWP)
- Outcome
- Association between leptin levels in blood and CWP (2019 criteria)
Main finding
As reported in the abstract
Leptin levelsOdds ratio (95% CI)P value
Unadjusted
1.014(1.007–1.020)
P < 0.001Adjusted for BMI, gender and age
1.008(1.000–1.017)
p 0.046Observational data: associations, not effects.
Further findings
CWP by leptin quartile groups
- Trend where higher leptin values gave higher OR for CWP
Original publication
High leptin levels in blood are associated with chronic widespread pain in rheumatoid arthritis. Arthritis Res Ther. Published 23 December 2024. doi:10.
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