Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis
Authors' conclusion
GUDCA was found to possess antioxidative, antiproliferative properties and an effective anti-inflammatory property at a low dosage.
Study context
- Population
- Plasma of rheumatoid arthritis (RA) patients; TNF-α induced SW982 cells; CIA rat modelmetabolomics n = 20
- Outcome
- Differential plasma metabolites and proteins in RA (untargeted metabolomics and SWATH proteomics) and effects of GUDCA in vitro and in vivo
Methodological detailsuntargeted metabolomics, proteomics (SWATH), in vitro (TNF-α induced SW982 cells), CIA rat model
- Untargeted metabolomics
- Proteomics (SWATH)
- In vitro (TNF-α induced SW982 cells)
- CIA rat model
Main finding
As reported in the abstract
Metabolites revealed
82
Differential proteins revealed
231
Original publication
Integrative metabolomic-proteomic analysis uncovers a new therapeutic approach in targeting rheumatoid arthritis. Arthritis Res Ther. Published 23 December 2024. doi:10.
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