Lupus & antiphospholipid syndrome
Medication Cost Concerns and Disparities in Patient-Reported Outcomes Among a Multiethnic Cohort of Patients With Systemic Lupus Erythematosus
Authors' conclusion
More than a quarter of participants reported at least 1 medication cost concern, which was associated with worse PROs.
Study context
- Population
- Multiethnic cohort of individuals with physician-confirmed systemic lupus erythematosus (SLE) (California Lupus Epidemiology Study)multiethnic SLE cohort
- Participants
- 334 participants
- Exposure
- Medication cost concerns vs no medication cost concerns
- Medication cost concernsn = 91
- Outcome
- Association of self-reported medication cost concerns with PROs (SLAQ, PHQ-8, PROMIS)
Methodological detailscross-sectional and longitudinal analyses, linear regression and mixed effects models, adjusted for age, sex, race and ethnicity, income, principal insurance, immunomodulatory medications, and organ damage
- Cross-sectional and longitudinal analyses
- Linear regression and mixed effects models
- Adjusted for age, sex, race and ethnicity, income, principal insurance, immunomodulatory medications, and organ damage
Main finding
As reported in the abstract
PROs, cross-sectional (adjusted)
Β (Systemic Lupus Activity Questionnaire (SLAQ))
5.9
95% CI 4.3–7.6P < 0.001
worse SLAQ
Β (PHQ-8)
2.7
95% CI 1.4–4.0P < 0.001
worse PHQ-8
Β (Patient-Reported Outcomes Measurement Information System (PROMIS) physical function)
−4.6
95% CI −6.7 to −2.4P < 0.001
worse PROMIS physical function
Medication cost concerns
27%
91
Observational data: associations, not effects.
Further findings
Change in patient-reported outcomes (PROs), longitudinal · 2-year follow-up
- Medication cost concerns not associated with significant changes in PROs
Original publication
Medication Cost Concerns and Disparities in Patient-Reported Outcomes Among a Multiethnic Cohort of Patients With Systemic Lupus Erythematosus. J Rheumatol. Published 15 June 2023. doi:10.
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