Maternal and Personal Smoking, Genetic Susceptibility, and Risk of Osteoarthritis: A Population‐Based Prospective Cohort Study
Authors' conclusion
Both maternal and personal smoking are independently associated with an elevated risk of OA. These associations are universal across different genetic susceptibility of OA.
Study context
- Population
- UK Biobank participants without osteoarthritis (OA) at baseline (mean age 56 years, 55% women)UK Biobank
- Participants
- 321,075 participants
- Exposure
- Maternal smoking and personal smoking and risk of OA
- Outcome
- Incident knee, hip, hand, and overall OA
Methodological detailspopulation-based, Cox proportional hazards models, polygenic risk scores
- Population-based
- Cox proportional hazards models
- Polygenic risk scores
Main finding
As reported in the abstract
Knee, hip, hand, and overall OA
Hazard ratio
1.08-1.23
Maternal smoking vs No maternal smoking
Hazard ratio
1.18-1.40
Personal smoking vs Never smoking
- Incident knee OA
- 18,470 (5.8%)
- Incident hip OA
- 12,064 (3.8%)
- Incident hand OA
- 6,605 (2.1%)
- Incident overall OA
- 52,853 (16.5%)
Observational data: associations, not effects.
Further findings
Dose-response: personal smoking dose (pack-years) and OA risk
- Significant dose-responsive associations
- P for trend < 0.05
Smoking–OA association across polygenic risk scores (PRS) strata
- Similar across different PRS strata
Original publication
Maternal and Personal Smoking, Genetic Susceptibility, and Risk of Osteoarthritis: A Population‐Based Prospective Cohort Study. Arthritis Care Res (Hoboken). Published 28 April 2026. doi:10.
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