Factors associated with radiographic progression of hand osteoarthritis over 2 years
Authors' conclusion
Over 2 years, a considerable proportion of patients demonstrated radiographic progression. Progressors were especially those with erosive disease, more radiographic damage (most pronounced in younger females) and bone marrow lesions at baseline.
Study context
- Population
- Patients with hand OA from a rheumatology outpatient clinic (Hand OSTeoArthritis in Secondary (HOSTAS) cohort; mean age 61 years, 86% female)
- Participants
- 417 patients
- Outcome
- Radiographic progression (osteophytes and JSN, OARSI) classified by smallest detectable change
- Follow-up
- 2 years
Methodological detailsHOSTAS cohort, rheumatology outpatient clinic, blinded, paired, chronological radiograph scoring (OARSI), logistic regression
- HOSTAS cohort
- Rheumatology outpatient clinic
- Blinded, paired, chronological radiograph scoring (OARSI)
- Logistic regression
Main finding
As reported in the abstract
Radiographic progression
Osteophyte progression
272
65%
Osteophyte sum score change, median (IQR)
1
0–2
Joint space narrowing (JSN) progression
135
32%
JSN sum score change, median (IQR)
1
0–2
Observational data: associations, not effects.
Further findings
Factors associated with progression
- Both osteophyte and JSN progressors had more radiographic damage at baseline
- Baseline erosive disease or bone marrow lesions associated with osteophyte progression in IP joints
- Female sex associated with osteophyte progression in thumb-base joints
- Association of baseline osteophytes with change in osteophytes strongest in younger females
Original publication
Factors associated with radiographic progression of hand osteoarthritis over 2 years. RMD Open. Published 24 April 2026. doi:10.
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