Sjögren's disease & overlap diseases
Lymphoma in Sjögren’s syndrome: no need for repetitive screening ultrasounds of the major salivary glands and neck in asymptomatic patients
Authors' conclusion
pSS patients with neither signs of lymphoma nor increased systemic disease activity did not benefit from screening.
Study context
- Population
- Patients with pSS undergoing US of the major salivary glands and neck134 patients · 1031 patient-years
- Participants
- 569 vs 179
- Exposure
- Screening US of major salivary glands and neck in asymptomatic patients vs occasion-related imaging
- Screening examinationsn = 569
- Occasion-relatedn = 179
- Outcome
- Usefulness and adverse effects of US of the major salivary glands and neck as lymphoma screening
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Lymphoma detected by imaging
Screening examinations
0
events
Occasion-related
6.1%
95% CI 3.5–10.6%
Observational data: associations, not effects.
Further findings
- Follow-up imaging recommended after screening examination — Screening examinations
- 17.1% (95% CI 14.2–20.4%)
Lymphoma diagnosed
- Lymphoma diagnosed in 15 patients (11.2%), all with clinical signs of lymphoma at diagnosis
Safety
- Invasive exclusion of lymphoma after screening examination — Screening examinations
- 0.5% (95% CI 0.1–1.5%)
Original publication
Lymphoma in Sjögren’s syndrome: no need for repetitive screening ultrasounds of the major salivary glands and neck in asymptomatic patients. Scand J Rheumatol. Published 15 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →