Lupus & antiphospholipid syndrome
Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials
Authors' conclusion
Based on pooled RCT data, there was no significant difference in 12-month renal responses between patients receiving low-dose prednisone following intravenous GC compared with those receiving initial high doses. SAEs were less frequent in patients receiving low-dose initial GC.
Study context
- Population
- Patients with lupus nephritis (LN) in standard of care (SOC) treatment arms of randomised controlled trials (RCTs) assessing variable glucocorticoids (GC) dosesSOC arms of RCTs
- Participants
- 417 vs 521
- Comparison
- Low initial oral GC dose vs high dose
- Low dosen = 417
- High dosen = 521reference
- Outcome
- CRR 0.5 (complete renal response requiring urine protein-creatinine ratio <0.5 mg/mg)
- Follow-up
- 12 months
Methodological detailspooled analysis of published data, SOC treatment arms
- Pooled analysis of published data
- SOC treatment arms
Pooled result
As reported in the abstract
CRR 0.5
P = 0.54
Further pooled results
CRR or PRR · 12 months
P = 0.14
Safety
SAEs · 12 months
P < 0.001
Infection SAEs · 12 months
P = 0.012
Original publication
Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials. Lupus Sci Med. Published 6 January 2025. doi:10.
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