Lupus & antiphospholipid syndrome
Utilisation patterns of immunomodulators and pregnancy outcomes in systemic lupus erythematosus: Insights from Korean national data
Authors' conclusion
Insufficient usage of hydroxychloroquine and PC-IS, along with a reduction in PIC-IS usage primarily during early pregnancy rather than before conception, highlights the unmet need for preconceptional family planning with appropriate medication management strategies in SLE pregnancies.
Study context
- Population
- Pregnancies initiated between 2005 and 2017 in systemic lupus erythematosus (SLE) patients, Koreapregnancies in 3,120 SLE patients
- Participants
- 5,044 pregnancies
- Outcome
- Immunomodulator use during the first trimester
- Follow-up
- First trimester
Methodological detailsNational Health Information Database in Korea, 2002–2018
- National Health Information Database in Korea
- 2002–2018
Main finding
As reported in the abstract
Pregnancy compatible immunosuppressant (PC-IS) use
10.7%
HCQ use
41.4%
Pregnancy incompatible immunosuppressant (pregnancy incompatible immunosuppressants (PIC-IS)) prescription rate
0.9%
Observational data: associations, not effects.
Further findings
Pregnancy outcomes (live births, stillbirths, abortions) · 2005 to 2017
- Incidence of live births, stillbirths and abortions remained consistent from 2005 to 2017
Original publication
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