Lupus & antiphospholipid syndrome
Increased risk of congenital malformations in offspring born to women with systemic lupus erythematosus in South Korea: a nationwide population-based study
Authors' conclusion
This nationwide population-based study in South Korea indicates that compared with the general population, neonates born to SLE mothers have a slightly increased risk of congenital malformations affecting the nervous system, head and neck, cardiovascular system, and musculoskeletal system.
Study context
- Population
- Korean women who had a singleton pregnancy, South Korea0.1% had systemic lupus erythematosus (SLE)
- Participants
- 3,279,204 women
- Exposure
- Women with SLE vs women without SLE
- Outcome
- Congenital malformations in offspring
Methodological detailsmultivariable analysis, propensity-matched sensitivity analysis
- Multivariable analysis
- Propensity-matched sensitivity analysis
Main finding
As reported in the abstract
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Congenital malformations by organ system (adjusted for age, parity, hypertension, diabetes, fetal sex)SLEvs Without SLENervous system | 1.90 (1.20–3.03) | |
| Congenital malformations by organ system (adjusted for age, parity, hypertension, diabetes, fetal sex)SLEvs Without SLEEye, ear, face, and neck | 1.37 (1.09–1.71) | |
| Congenital malformations by organ system (adjusted for age, parity, hypertension, diabetes, fetal sex)SLEvs Without SLECirculatory system | 1.91 (1.67–2.20) | |
| Congenital malformations by organ system (adjusted for age, parity, hypertension, diabetes, fetal sex)SLEvs Without SLEMusculoskeletal system | 1.26 (1.05–1.52) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Congenital malformations after propensity matching (sensitivity analysis)
- Some of the tendencies were maintained
Original publication
Increased risk of congenital malformations in offspring born to women with systemic lupus erythematosus in South Korea: a nationwide population-based study. RMD Open. Published 2 June 2023. doi:10.
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