Lupus & antiphospholipid syndrome
Low disease activity state associated with fewer incident vertebral fractures in Mestizo women with systemic lupus erythematosus
Authors' conclusion
LDAS ≥50% of the time was significantly associated with a diminished risk of new VF in Mestizo women with SLE, even in patients not in remission. However, LDAS did not help modify BMD changes over time.
Study context
- Population
- Mestizo women with systemic lupus erythematosus (SLE), median 8-year follow-up35 (31.8%) with new VF
- Participants
- 110 women
- Exposure
- Low disease activity state (LDAS) ≥50% of the observation time vs not
- LDAS-50n = 56
- Outcome
- New (incident) VF
Methodological detailslongitudinal, observational, interval-censored survival regression
- Longitudinal
- Observational
- Interval-censored survival regression
Main finding
As reported in the abstract
Incident VF
LDAS-50 vs No LDAS-50Hazard ratio (95% CI)
Univariable
0.16(0.06–0.49)
Adjusted for age, BMI, menopause, prevalent VF, baseline BMD, cumulative GC use, anti-osteoporotic therapy
0.39(0.16–0.98)
Observational data: associations, not effects.
Further findings
- No association between LDAS and bone mineral density (BMD) measurement changes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Low disease activity state associated with fewer incident vertebral fractures in Mestizo women with systemic lupus erythematosus. Lupus. Published 13 September 2023. doi:10.
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