Systemic sclerosis & Raynaud's
Long-term organ damage accrual and late mortality in systemic sclerosis
Authors' conclusion
Factors associated with damage accrual in SSc patients with long-term follow-up were identified. Higher SCTC-DI and higher SCTC-DI annual rise were associated with late mortality in SSc.
Study context
- Population
- Patients with systemic sclerosis (SSc) with a baseline visit at diagnosis and at least 10 years of follow-up after diagnosis
- Participants
- 253 patients
- Outcome
- Long-term evolution of organ damage accrual measured by SCTC-DI
- Follow-up
- 10 years after diagnosis
Methodological detailssingle-centre, multivariable analyses
- Single-centre
- Multivariable analyses
Main finding
As reported in the abstract
Organ damage accrual (SCTC-DI)
Moderate or severe damage at 10 years
34%
Observational data: associations, not effects.
Further findings
Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI) score and annual rise by subset and ACA status · During follow-up
- Higher SCTC-DI score and higher annual rise in dcSSc than in lcSSc
- Higher SCTC-DI score and higher annual rise in ACA-negative than in ACA+
Factors associated with moderate or severe damage
- dcSSc, lack of ACA and SCTC-DI scores at previous timepoints independently associated with moderate or severe damage
- Multivariable analyses
SCTC-DI and late mortality (death >10 years after diagnosis)
- SCTC-DI significantly higher at baseline and at every timepoint, with a higher annual rise, in late mortality vs surviving patients
Original publication
Long-term organ damage accrual and late mortality in systemic sclerosis. Clin Exp Rheumatol. Published 15 June 2023. doi:10.
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