Systemic sclerosis & Raynaud's
Accrual of organ damage and one-year mortality in systemic sclerosis: A prospective observational study
Authors' conclusion
Cumulative damage was associated with disease duration, mRSS, CRP concentration, and a decline in EQ-5D, while the risk of death at 12 months was primarily associated with high SCTC-DI and low EQ-5D VAS.
Study context
- Population
- Patients with systemic sclerosis (SSc), single centre97.3% females
- Participants
- 75 patients
- Outcome
- SCTC-DI and all-cause mortality
- Follow-up
- 12 months
Methodological detailssingle-centre, cross-sectional and 12-month longitudinal follow-up, multivariate models
- Single-centre
- Cross-sectional and 12-month longitudinal follow-up
- Multivariate models
Main finding
As reported in the abstract
- Scleroderma Clinical Trials Consortium Damage Index (SCTC-DI), median (IQR)
- 4(6)
- Severe SCTC-DI (≥13)
- 4 (5.3%)
- Factors associated with SCTC-DI: disease duration β
- 0.276
- Modified Rodnan Skin Score (mRSS) β
- 0.287
- C-reactive protein (CRP) β
- 0.311
- EQ-5D β
- −0.207
- Deaths at 1 year
- 4
- Mortality at 12 months: baseline SCTC-DI ≥13, OR
- 44.5 (95% CI 1.6-1237.9; p = 0.025)
- Mortality at 12 months: EQ-5D visual analog scale (VAS), OR
- 0.9 (95% CI 0.8-0.9; p = 0.018)
Observational data: associations, not effects.
Original publication
Accrual of organ damage and one-year mortality in systemic sclerosis: A prospective observational study. Semin Arthritis Rheum. Published 4 December 2024. doi:10.
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