Lupus & antiphospholipid syndrome
LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression
Authors' conclusion
LncRNA NRIR may be a potential biomarker for SLE and is likely involved in the progression of SLE.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients and healthy individuals
- Participants
- 110 patients
- Comparison
- SLE patients vs healthy individuals
- SLEn = 55
- Healthyn = 55reference
- Outcome
- Expression and diagnostic significance of lncRNA NRIR in SLE
Methodological detailscase-control, qRT-PCR, ROC curve analysis, dual-luciferase reporter assay
- Case-control
- qRT-PCR
- ROC curve analysis
- Dual-luciferase reporter assay
Performance
As reported in the abstract
NRIR expression and diagnostic value
- Upregulated NRIR expression in SLE, serving a diagnostic function for SLE
Further findings
CD4+ T-cell viability
- Abnormal NRIR expression impacted viability of CD4+ T cells in SLE
miR-31-5p expression
- NRIR negatively modulates miR-31-5p expression
Original publication
LncRNA NRIR serves as a biomarker for systemic lupus erythematosus and participates in the disease progression. Lupus. Published 20 October 2024. doi:10.
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