Lupus & antiphospholipid syndrome
Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus
Authors' conclusion
In this large international study, more than 40% of patients with SLE were not active enough. We found an inverse association between PA levels and fatigue, pain, stress or depression.
Study context
- Population
- Patients with SLE in a large international cohort (LEAF participants)986 (95.8%) women
- Participants
- 1,029 patients
- Outcome
- PA level (METs, IPAQ; low, moderate, high PA)
Methodological detailsinternational cohort, patient-reported instruments via LEAF digital tool
- International cohort
- Patient-reported instruments via LEAF digital tool
Main finding
As reported in the abstract
PA level (IPAQ)
Physical expenditure, median (IQR) metabolic equivalent of tasks (METs)/week
936
297–2622
Low physical activity (PA) level
456
44.3%
Observational data: associations, not effects.
Further findings
Association of lower PA (International Physical Activity Questionnaire (IPAQ)) with symptoms
- Increased fatigue (FACIT-Fatigue) more prevalent in less active patients
- P < 0.0001
- Increased fatigue (Multidimensional Fatigue Inventory) more prevalent in less active patients
- P < 0.0001
- Increased fatigue (VAS) more prevalent in less active patients
- P = 0.02
- Pain more prevalent in less active patients
- P = 0.009
- Depression more prevalent in less active patients
- P = 0.02
- Stress more prevalent in less active patients
- P < 0.0001
Original publication
Levels of physical activity in a large international cohort of patients with systemic lupus erythematosus. Lupus Sci Med. Published 15 March 2025. doi:10.
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