Lupus & antiphospholipid syndrome
Landscape of immune cells in systematic lupus erythematosus patients with Epstein–Barr virus infection: assessed by single-cell sequencing
Authors' conclusion
This study provides a comprehensive characterization of the immune cell profiles and BCR repertoires of patients with SLE, both with and without concurrent EBV infections, contributing to a better understanding of the mechanism underlying the immune response to EBV infection in patients with SLE.
Study context
- Population
- Patients with SLE with or without EBV infection, and healthy controls83,478 cells · 31 subtypes
- Participants
- 2 / 4 / 2
- Comparison
- SLE with EBV infection vs SLE without EBV infection vs healthy controls
- SLE-EBV+n = 2
- SLE-EBV-n = 4reference
- Healthy controlsn = 2
- Outcome
- Immune cell and BCR profiles
Methodological detailssingle-cell RNA sequencing, B-cell receptor (BCR) repertoire analysis
- Single-cell RNA sequencing
- BCR repertoire analysis
Main finding
As reported in the abstract
- Proportion of CD8+ proliferation T cells higher in SLE-EBV+ than SLE-EBV-
- IFN-α/β pathways upregulated in most T cells, monocytes and B cells in SLE-EBV+ vs SLE-EBV-
- T-cell trajectory indicated CD4+ Tregs may play crucial roles in SLE with EBV infection
- IGHV3 and IGHV4 gene families frequently present in BCR heavy chain in all groups
- IgM largest of five Ig isotypes, but proportion significantly decreased in SLE-EBV+
Original publication
Landscape of immune cells in systematic lupus erythematosus patients with Epstein–Barr virus infection: assessed by single-cell sequencing. Rheumatology (Oxford). Published 11 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →