Systemic sclerosis & Raynaud's
Kinetics of response to iloprost evaluated by laser speckle contrast analysis in systemic sclerosis
Authors' conclusion
This LASCA study highlights the transience of the vasoactive effect of ILO, with a perfusion benefit that is completely lost after 1 month.
Study context
- Population
- Adult systemic sclerosis (SSc) patients in stable therapy with outpatient iloprost (ILO) (6 h for 2 consecutive days every 4 weeks)77.8% female, mean age 61.5 years
- Participants
- 27 patients
- Exposure
- Peripheral finger perfusion at five time points around an ILO course
- SScn = 27
- Outcome
- Kinetics of response to ILO: peripheral finger perfusion assessed by LASCA
- Follow-up
- D1pre, D1post, D2pre, D2post and D30
Methodological detailssingle-group, repeated laser speckle contrast analysis (LASCA) evaluations
- Single-group
- Repeated LASCA evaluations
Main finding
As reported in the abstract
Finger perfusion by LASCA
- Increase in perfusion at the end of each ILO course
- On the second day (D1pre vs D2pre and D2pre vs D2post) the increase no longer significant in half of the fingers
- Compared with D1post, most fingers showed a significant reduction in perfusion at the beginning of the second ILO day
- No statistically significant differences between perfusion at D1pre and D30 (after 1 month)
Observational data: associations, not effects.
Original publication
Kinetics of response to iloprost evaluated by laser speckle contrast analysis in systemic sclerosis. Scand J Rheumatol. Published 26 July 2022. doi:10.
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