Systemic sclerosis & Raynaud's
FLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis
Main finding · FLT3 rs76428106-C allele frequencyResult — go to the resultOdds ratio 1.34Authors' conclusion
This study is the first to report an association between rs76428176-C and SSc.
Study context
- Population
- European ancestry individuals: Systemic sclerosis (SSc) patients and healthy controls
- Participants
- 26,598 individuals
- Comparison
- SSc patients vs healthy controls, FLT3 rs76428106-C allele
- SScn = 9,063
- Healthy controlsn = 17,535reference
- Outcome
- Association between FLT3 rs76428106-C and SSc susceptibility
Methodological detailsimputation of genome-wide association study data, logistic regression
- Imputation of genome-wide association study data
- Logistic regression
Main finding
FLT3 rs76428106-C allele frequency
Odds ratio
1.34
P = 2.03 × 10-3
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| rs76428106-C frequency, SSc with vs without digital ulcers | 2.16 | P = 0.036 |
rs76428106-C in main SSc clinical and serological subgroups vs controls
- A similar risk effect was found when the main SSc clinical and serological subgroups were compared with controls
Original publication
FLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis. Rheumatology (Oxford). Published 25 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →