Spondyloarthritis & psoriatic arthritis
Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis
Authors' conclusion
The serum biomarker panel of C3M, C4M, PRO-C3, PRO-C6, and CPa9-HNE reflecting synovitis, enthesitis, and neutrophil activity may serve as novel tool for quantitatively monitoring flares in PsA patients.
Study context
- Population
- Psoriatic arthritis (PsA) patients with flares, early-diagnosed PsA without flare, controls, and osteoarthritis (OA) patients
- Comparison
- PsA-flare vs controls and PsA without flare; PsA-flare vs OA
- Outcome
- Serum protease-mediated biomarkers, PsA-flare vs PsA without flare and controls
Methodological detailscase-control comparison
- Case-control comparison
Main finding
As reported in the abstract
- AUC of VICM, PsA-flare vs PsA without flare
- 0.71
- AUC of CPa9-HNE, PsA-flare vs PsA without flare
- 0.89
- AUC of CRPM, PsA-flare vs PsA without flare
- 0.76
- AUC of PRO-C3, PsA-flare vs PsA without flare
- 0.86
- AUC of 5-marker serum panel (C3M, C4M, PRO-C3, PRO-C6, CPa9-HNE), PsA-flare vs PsA without flare
- 0.98
Observational data: associations, not effects.
Further findings
Synovial fluid biomarkers, PsA-flare vs OA
- VICM significantly elevated and PRO-C2 significantly reduced in PsA-flare vs OA
Original publication
Investigating protease-mediated peptides of inflammation and tissue remodeling as biomarkers associated with flares in psoriatic arthritis. Arthritis Res Ther. Published 27 May 2024. doi:10.
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