Intrinsic capacity is associated with fracture risk in older women with osteoporosis
Authors' conclusion
Lower IC was associated with a higher estimated risk of fragility fractures in postmenopausal women, supporting the potential value of IC as a complementary component of fracture risk assessment in older adults.
Study context
- Population
- Postmenopausal women attending an outpatient clinic for osteo-metabolic disorderswomen enrolled (mean age 68.1 ± 8.6 years)
- Participants
- 200 women
- Outcome
- Impairment in more than one IC domain, of the 200 women enrolled
Methodological detailsconsecutive enrolment
- Consecutive enrolment
Main finding
As reported in the abstract
Women with impairment in more than one Intrinsic Capacity (IC) domain, of the 200 enrolled
195
97.5%
Further findings
Prevalence of fragility fractures, by preserved vision
| OR (95% CI) | ||
|---|---|---|
| Preserved vision | 0.2545 (0.0693–0.9349) | |
| 0.050.21520Odds ratio (log scale) |
High estimated fracture risk
| OR (95% CI) | ||
|---|---|---|
| Hearing lossIndependently associated | 2.3908 (1.2689–4.5046) | |
| MalnutritionIndependently associated | 4.0114 (1.5091–10.6630) | |
| Limited mobilityIndependently associated | 2.7898 (1.4650–5.3127) | |
| 0.050.21520Odds ratio (log scale) |
Lower lumbar spine bone mineral density (BMD) (T-score < −2.5 SD), by limited mobility
| OR (95% CI) | ||
|---|---|---|
| Limited mobilityReported as associated with lower lumbar spine BMD | 0.4370 (0.2416–0.7904) | |
| 0.20.5125Odds ratio (log scale) |
- Prevalence of fragility fractures, by preserved vision: independently associated with a lower prevalence of fragility fractures
Number of impaired IC domains and 10-year probability of major osteoporotic fractures (FRAX)
- Correlation, r
- r = 0.392, p < 0.001
Original publication
Intrinsic capacity is associated with fracture risk in older women with osteoporosis. Osteoporos Int. Published 4 November 2026. doi:10.
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