Hospitalisation and subsequent fracture risk—a national matched cohort study in Denmark
Main finding · Major osteoporotic fracture (MOF), fully adjusted modelResult — go to the resultHazard ratio 1.77 CI 1.47–2.14Authors' conclusion
There is a time-dependent sex-specific association between hospitalisation and MOF, supported by several dose-dependencies.
Study context
- Population
- Individuals aged >45 years in Danish registry data; individuals with at least one day in hospital during 2023 and matched controls
- Exposure
- Hospitalisation vs matched controls
- Outcome
- Major osteoporotic fracture (MOF), fully adjusted model
- Follow-up
- 14 days
Methodological detailsmatched to controls using age, sex, and comorbidities, Danish registry data, time-to-event analyses, cumulative incidence with two-step adjustment for the competing risk of mortality, cause-specific Cox proportional hazards models adjusted for confounders
- Matched to controls using age, sex, and comorbidities
- Danish registry data
- Time-to-event analyses
- Cumulative incidence with two-step adjustment for the competing risk of mortality
- Cause-specific Cox proportional hazards models adjusted for confounders
Main finding
As reported in the abstract
Hazard ratio
1.77
CI 1.47–2.14
HOSPITALISEDvs CONTROLS
HR 1.77 (CI 1.47–2.14)
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | |
|---|---|---|
| Major osteoporotic fracture (MOF), fully adjusted model · 30 daysFully adjusted model | 1.28 (1.12–1.47) | |
| MOF in females (subgroup) · 90 days | 0.93 (0.84–1.03) | |
| 0.512Hazard ratio (log scale) |
| Outcome | HR |
|---|---|
| Major osteoporotic fracture (MOF), fully adjusted model · one yearFully adjusted model | 1.03 |
| Major osteoporotic fracture (MOF), fully adjusted model · complete follow-upFully adjusted model | 1.10 |
- MOF in females (subgroup): females; temporary normalisation of MOF cumulative incidence and cause-specific risk, in contrast to males
MOF in females (subgroup) · 90 days
- Females had consistently higher MOF rates
Dose-response for hospitalisation duration and count
- Significant dose-response associations were reported for hospitalisation duration and count
Original publication
Hospitalisation and subsequent fracture risk—a national matched cohort study in Denmark. Osteoporos Int. Published 30 October 2026. doi:10.
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