Lupus & antiphospholipid syndrome
Interstitial palladin is associated with tubulointerstitial chronicity and adverse outcomes in patients with lupus nephritis
Authors' conclusion
Interstitial palladin expression may reflect tubulointerstitial chronicity and be associated with poor outcomes in LN; however, its independent prognostic value could not be established due to the limited number of events.
Study context
- Population
- Japanese patients with biopsy-proven lupus nephritis (LN), Kanazawa University Hospital, 1990–2018biopsy-proven LN
- Participants
- 34 patients
- Exposure
- High vs low interstitial palladin expression
- Outcome
- Association of interstitial palladin (log2 palladin-positive area) with modified NIH activity and chronicity indices; event-free survival for RRT initiation or all-cause death
Methodological detailssingle-centre, biopsy-proven
- Single-centre
- Biopsy-proven
Main finding
As reported in the abstract
Correlation of log2 palladin with histopathology (Spearman)
- Modified NIH chronicity index
- ρ = 0.61, p < 0.01
- Tubular atrophy
- ρ = 0.53, p < 0.01
- Interstitial fibrosis
- ρ = 0.56, p < 0.01
- Interstitial inflammation
- ρ = 0.55, p < 0.01
- Total activity index (not correlated)
- ρ = 0.24, p = 0.16
Observational data: associations, not effects.
Further findings
Events
| Outcome | High-palladin | Low-palladin | P value |
|---|---|---|---|
| Composite outcome (RRT initiation or all-cause death) · median follow-up 10.1 years (IQR, 3.3-17.5)High palladin associated with poorer event-free survival | 5 | 2 | log-rank p = 0.04 |
- Composite outcome (renal replacement therapy (RRT) initiation or all-cause death) — Patients reaching the composite outcome
- 7
Original publication
Interstitial palladin is associated with tubulointerstitial chronicity and adverse outcomes in patients with lupus nephritis. Lupus. Published 19 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →