Lupus & antiphospholipid syndrome
Prevalence of falls in a pooled US cohort of adults with systemic lupus erythematosus: a nested cross-sectional study
Authors' conclusion
The prevalence of falls in SLE is high and recurrence is common
Study context
- Population
- Adults with systemic lupus erythematosus (SLE), pooled population-based cohorts in California (3/2025–2/2026) and Georgia (10/2019–5/2022) (mean age 47.9; 91.9% women)pooled SLE cohort
- Participants
- 780 adults
- Exposure
- SLE cohort vs 2023 US population estimates
- Outcome
- Prevalence of any fall in the prior year
- Follow-up
- Prior year
Methodological detailsnested within two pooled population-based SLE cohorts, logistic regression marginal estimates, age- and sex-standardised comparison with US population
- Nested within two pooled population-based SLE cohorts
- Logistic regression marginal estimates
- Age- and sex-standardised comparison with US population
Main finding
As reported in the abstract
Any fall in the prior year
SLE
26.0%
Observational data: associations, not effects.
Further findings
Age- and sex-standardised fall prevalence, ages ≥45
Recurrent falls (≥2) and fall-related injuries among those who fell · prior year
- Falling two times or more
- 59.1%
- Associated injuries
- 31.0%
Fall prevalence by correlates (statistically significantly associated with higher fall prevalence)
- Age ≥65 vs 20-44
- 37.4% vs 20.7%
- Higher vs lower SLE activity
- 38.5% vs 13.5%
- Moderate-to-severe depressive symptoms vs not
- 40.0% vs 23.7%
- Greater vs less pain interference
- 43.8% vs 16.5%
- Greater vs less fatigue
- 39.2% vs 18.8%
- Lower vs higher cognitive function
- 39.7% vs 18.9%
Age- and sex-standardised fall prevalence, ages ≥45
- SLE estimate similar to US population estimate
Original publication
Prevalence of falls in a pooled US cohort of adults with systemic lupus erythematosus: a nested cross-sectional study. Lupus Sci Med. Published 17 August 2026. doi:10.
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