Lupus & antiphospholipid syndrome
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis at Cho Ray hospital, Vietnam
Authors' conclusion
The D allele and ID/DD genotypes are linked with the susceptibility of kidney failure in LN participants.
Study context
- Population
- Lupus nephritis (LN) participants at Cho Ray Hospital, Vietnam (12/2021–07/2023)
- Participants
- 208 participants
- Exposure
- Angiotensin-converting enzyme (ACE) I/D alleles and genotypes across 3 LN groups by kidney function and kidney replacement therapy (KRT) on admission
- Group 1n = 71reference
- Group 2n = 55
- Group 3n = 82
- Outcome
- Distribution of ACE I/D alleles and genotypes and correlation of ACE I/D polymorphism with kidney outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
D allele frequency
P = 0.003
Observational data: associations, not effects.
Further findings
DD genotype frequency · across 3 groups
P = 0.005
Kidney failure (eGFR ≤ 60 vs eGFR > 60) by genotype
- OR for DD genotype
- 8.26
- OR for ID genotype
- 2.31
KRT (KRT vs no KRT) by genotype
- OR for ID genotype
- 2.01
Original publication
Insertion/deletion polymorphism of the angiotensin-converting enzyme gene in lupus nephritis at Cho Ray hospital, Vietnam. Lupus. Published 4 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →