Lupus & antiphospholipid syndrome
Incidence and Factors Associated With Recurrent Pericarditis in Lupus
Authors' conclusion
In this study, recurrence was more likely within 1 year of the onset of pericarditis and among younger patients, those with uncontrolled disease, and those receiving oral prednisone therapy, with a dose-dependent association.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) and a history of pericarditis in the Hopkins Lupus Cohort, tertiary medical center, enrolled 1988–2023of 2931 in cohort
- Participants
- 590 patients
- Outcome
- Recurrence of pericarditis (episode ≥6 weeks after first recorded episode; pericarditis defined by SELENA-SLEDAI)
Methodological detailssingle-centre, retrospective analysis of a prospective cohort, multivariable analysis
- Single-centre
- Retrospective analysis of a prospective cohort
- Multivariable analysis
Main finding
As reported in the abstract
Recurrent pericarditis · median (IQR) follow-up 6.7 (2.5-13.6) years
Patients with recurrent pericarditis
120
20.3%
Recurrence rate per person-year of follow-up
0.053
95% CI 0.047–0.059
Only 1 recurrence among patients with recurrence
61
50.8%
2 or more recurrences among patients with recurrence
59
49.2%
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Factors associated with recurrence (multivariable analysis)Age ≥60 yearsvs Age <40 yearsRate ratio | 0.11 (0.04–0.32) | |
| Factors associated with recurrence (multivariable analysis)Prednisone ≥20 mgvs Prednisone 0 mgRate ratio | 1.99 (1.17–3.40) | |
| Factors associated with recurrence (multivariable analysis)SLEDAI ≥3vs SLEDAI 0Rate ratio | 1.55 (1.21–2.00) | |
| Factors associated with recurrence (multivariable analysis)3-10 years since initial episodevs <1 year since initial episodeRate ratio | 0.32 (0.20–0.52) | |
| 0.050.21520Relative risk (log scale) |
Original publication
Incidence and Factors Associated With Recurrent Pericarditis in Lupus. JAMA Netw Open. Published 3 February 2025. doi:10.
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