Influence of Multimorbidity on New Treatment Initiation and Achieving Target Disease Activity Thresholds in Active Rheumatoid Arthritis: A Cohort Study Using the Rheumatology Informatics System for Effectiveness Registry
Authors' conclusion
These findings from a large, real-world registry illustrate the potential impact of multimorbidity on treatment response
Study context
- Population
- Adults with active rheumatoid arthritis (RA) in the Rheumatology Informatics System for Effectiveness (RISE) registry; middle aged, female, predominantly White1,558 (RAPID3) and 834 (Clinical Disease Activity Index (CDAI)) new disease-modifying antirheumatic drug (DMARD)
- Participants
- 15,626 vs 5,733
- Exposure
- Multimorbidity burden in active RA
- RAPID3n = 15,626
- CDAIn = 5,733
- Outcome
- New DMARD initiation in active RA and, among those initiating a new DMARD, achieving low disease activity or remission
Methodological detailsregistry-based (RISE), multivariable logistic regression
- Registry-based (RISE)
- Multivariable logistic regression
Main finding
As reported in the abstract
Achieving treatment targets (low disease activity or remission) among those initiating a new DMARD, per 1-unit RxRisk
OR for achieving low disease activity or remission (95% CI)
Per 1-unit RxRisk (RAPID3 cohort)
0.95(0.91–0.98)
Per 1-unit RxRisk (CDAI cohort)
0.94(0.90–0.99)
Per 1-unit RxRisk, as printed
Observational data: associations, not effects.
Further findings
Achieving target RA disease activity, highest multimorbidity burden
| OR (95% CI) | ||
|---|---|---|
| RAPID3Highest burden of multimorbidity | 0.54 (0.34–0.85) | |
| CDAIHighest burden of multimorbidity | 0.65 (0.37–1.15) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Influence of Multimorbidity on New Treatment Initiation and Achieving Target Disease Activity Thresholds in Active Rheumatoid Arthritis: A Cohort Study Using the Rheumatology Informatics System for Effectiveness Registry. Arthritis Care Res (Hoboken). Published 10 September 2022. doi:10.
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