Vasculitis & polymyalgia rheumatica
Inflammation of the temporalis muscle and adjacent nerve tissue in giant cell arteritis: expanding the spectrum of inflammatory lesions
Authors' conclusion
Our results expand the spectrum of inflammatory lesions known to be associated with active C-GCA.
Study context
- Population
- Patients with active cranial GCA fulfilling the 2022 ACR/EULAR classification criteria whose temporal artery biopsy (TAB) specimens contained temporalis muscle
- Participants
- 11 vs 3
- Exposure
- Active cranial GCA vs non-GCA controls
- Cranial giant cell arteritis (C-GCA)n = 11
- Controlsn = 3reference
- Outcome
- Histopathological features of the temporalis muscle and adjacent nerve tissue
Methodological detailsretrospective clinical data, immunohistochemistry, non-GCA controls, Clinical, laboratory and imaging features retrospectively recorded from patient charts at time of biopsy
- Retrospective clinical data
- Immunohistochemistry
- non-GCA controls
- Clinical, laboratory and imaging features retrospectively recorded from patient charts at time of biopsy
Main finding
As reported in the abstract
- Temporalis muscle (TM) inflammation in C-GCA
- 10/11
- Adjacent nerve fascicle inflammation in C-GCA
- 7/11
- Sarcolemmal MHC class I upregulation in C-GCA
- 8/8
- Sarcolemmal MHC class II upregulation in C-GCA
- 6/11
- αB-Crystallin positivity (pre-necrotic myofibres) in C-GCA
- 10/11
Observational data: associations, not effects.
Original publication
Inflammation of the temporalis muscle and adjacent nerve tissue in giant cell arteritis: expanding the spectrum of inflammatory lesions. Rheumatology (Oxford). Published 15 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →