Vasculitis & polymyalgia rheumatica
Autoantibodies towards HFE and SYT5 in anti-neutrophil cytoplasm antibody-associated vasculitis relapse
Authors' conclusion
Through a broad protein array-based autoantibody screening, we identified two novel autoantibodies directed against HFE and SYT5 as candidate biomarkers of relapse in AAV.
Study context
- Population
- ANCA-associated vasculitis (AAV) patients in remission
- Participants
- 246 patients
- Comparison
- AAV patients with multiple relapses vs patients in long-term remission off therapy
- Outcome
- Novel autoantibodies associated with relapse risk
Methodological detailsprotein array-based autoantibody screening, LASSO regression, Screened with in-house protein arrays of 42 000 protein fragments representing 18 000 unique human proteins
- Protein array-based autoantibody screening
- LASSO regression
- Screened with in-house protein arrays of 42 000 protein fragments representing 18 000 unique human proteins
Main finding
As reported in the abstract
Autoantibodies associated with relapse
Autoantibodies at higher frequency in multiple relapses vs long-term remission off therapy
9
Autoantibodies associated with relapse occurrence after sample collection (LASSO)
6
Original publication
Autoantibodies towards HFE and SYT5 in anti-neutrophil cytoplasm antibody-associated vasculitis relapse. Rheumatology (Oxford). Published 14 October 2024. doi:10.
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