Vasculitis & polymyalgia rheumatica
Anti-neutrophil cytoplasmic antibody patterns can predict clinical relapse in ANCA-associated vasculitis: overall population and subgroups
Authors' conclusion
Persistently positive and re-positive ANCA and infections predict clinical relapse in AAV, especially in patients with MPO-AAV and renal involvement.
Study context
- Population
- Newly diagnosed Antibody-associated Vasculitis (AAV), Affiliated Hospital of Qingdao University, January 2016 through November 2021
- Participants
- 132 participants
- Exposure
- ANCA patterns and infections as predictors of clinical relapse
- Outcome
- Clinical relapse
Methodological detailssingle-centre, univariate and multivariate regression, K-M survival curve
- Single-centre
- Univariate and multivariate regression
- K-M survival curve
Main finding
As reported in the abstract
Clinical relapse, overall population
Hazard ratio (95% CI)P value
Persistent positive patternANCA patterns overall p<0.001
3.352(1.463~7.678)
P = 0.004Positive conversion pattern
4.760(2.094~10.820)
P < 0.001Infections
4.684(1.980~11.079)
P < 0.001- Relapse rate highest in the positive conversion group
- P < 0.001
Observational data: associations, not effects.
Further findings
Clinical relapse, MPO-AAV (subgroup)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Persistent positive patternANCA patterns overall p=0.001 | 4.495 (1.508~13.396) | P = 0.007 | |
| Positive conversion pattern | 7.404 (2.652~20.671) | P < 0.001 | |
| Infections | 3.594 (1.511~8.547) | P = 0.004 | |
| 0.050.21520Hazard ratio (log scale) |
Clinical relapse, renal involvement (subgroup)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Persistent positive patternANCA patterns overall p=0.004 | 3.618 (1.364~9.592) | P = 0.01 | |
| Positive conversion pattern | 4.492 (1.778~11.352) | P < 0.001 | |
| Infections | 7.791 (2.511~24.174) | P < 0.001 | |
| 0.050.21520Hazard ratio (log scale) |
Clinical relapse, without renal involvement (subgroup)
- ANCA patterns and infections not significantly associated with relapse
Original publication
Anti-neutrophil cytoplasmic antibody patterns can predict clinical relapse in ANCA-associated vasculitis: overall population and subgroups. Clin Exp Rheumatol. Published 27 July 2022. doi:10.
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