Infections as a predominant cause of death in adult patients with idiopathic inflammatory myopathies
Authors' conclusion
Patients with IIM associated with cardiac involvement and concomitant autoimmune diseases may be at higher risk of fatal outcomes. Infections were the predominant cause of death in our cohort of patients. The majority of fatal outcomes occurred at the relatively early stage of the disease.
Study context
- Population
- Adults with idiopathic inflammatory myopathies (IIM) (mostly ASyS, DM and PM), single-centre Polish cohort
- Participants
- 79 adults
- Exposure
- Deceased vs survived IIM patients
- Deceasedn = 9
- Outcome
- Causes of death and risk factors for fatal outcomes
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mortality and causes of death
Deceased
11.39%
9
Deceased vs Survived: P = 0.026 · Deceased vs Survived: P = 0.028 · Deceased vs Survived: P = 0.005 · Deceased vs Survived: P = 0.006
- Deaths caused by infections, predominantly respiratory tract
- 89.89%
- Deaths within first 18 months after IIM diagnosis
- 77.78%
- Deaths caused by malignancy
- 0
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Factors more frequent in deceased vs survivorsDeceased vs Survived | P = 0.026 |
| Factors more frequent in deceased vs survivorsDeceased vs Survived | P = 0.028 |
| Factors more frequent in deceased vs survivorsDeceased vs Survived | P = 0.005 |
| Factors more frequent in deceased vs survivorsDeceased vs Survived | P = 0.006 |
Cohort characteristics
- Median diagnostic delay (months)
- 5
- Deaths within the first 18 months after IIM diagnosis
- 77.78%
- History of malignancy
- 10.13%
- Deaths caused by malignancy
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Infections as a predominant cause of death in adult patients with idiopathic inflammatory myopathies. Clin Exp Rheumatol. Published 26 February 2025. doi:10.
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