Lupus & antiphospholipid syndrome
Infection-related hospitalisation in young adults with systemic lupus erythematosus: data from the National Inpatient Sample
Authors' conclusion
YA- SLE had similar rates of SIH to adults with SLE.
Study context
- Population
- Hospital admissions with SLE in patients aged ≥18 years, National Inpatient Sample, 2010–2019hospital admissions with SLE
- Participants
- 1,720,883 admissions
- Exposure
- Young adults with SLE vs adults with SLE and vs young adults without SLE
- Outcome
- Rate of serious infection-related hospitalisation (SIH; sepsis, pneumonia, UTI, skin and soft tissue infections, opportunistic infections) in YA-SLE vs adults with SLE and vs YA-no SLE
Methodological detailsNational Inpatient Sample 2010–2019, time trends 2000–2019
- National Inpatient Sample 2010–2019
- Time trends 2000–2019
Main finding
As reported in the abstract
Rate of SIH
Young adults with SLE (YA-SLE) vs Adults with SLE: P = 0.12 · YA-SLE vs YA-no SLE: P < 0.001
Observational data: associations, not effects.
Further findings
Factors associated with SIH in YA-SLE
- Only race/ethnicity among sociodemographic factors was associated with SIH
- Comorbid lupus nephritis and pleuritis more prevalent in young adults than adults with SLE and SIH; both associated with SIH in YA-SLE
Time trends of SIH · 2000-2019
- Increasing rates of SIH over time, driven by sepsis
Most common SIH diagnosis among SLE with SIH
- Sepsis, followed by pneumonia
Original publication
Infection-related hospitalisation in young adults with systemic lupus erythematosus: data from the National Inpatient Sample. Lupus Sci Med. Published 5 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →