Spondyloarthritis & psoriatic arthritis
Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures
Authors' conclusion
More PsA patients than PsO patients and HCs reported sleep disturbances. Sleep disturbances were associated with inflammatory and non-inflammatory measures possibly explaining the limited effect of treatment.
Study context
- Population
- Patients from the Parker Institute's PsA patient cohort, plus psoriasis (PsO) patients and healthy controls (HCs)
- Participants
- 109 / 20 / 20
- Exposure
- PsA vs psoriasis vs healthy controls
- PsAn = 109
- PsOn = 20
- HCsn = 20reference
- Outcome
- Prevalence of sleep disturbances (PSQI)
Methodological detailscohort-based (Parker Institute PsA cohort), univariate and multivariate regression, mixed-effect model for repeated measures
- Cohort-based (Parker Institute PsA cohort)
- Univariate and multivariate regression
- Mixed-effect model for repeated measures
Main finding
As reported in the abstract
Sleep disturbances reported (PSQI)
Observational data: associations, not effects.
Further findings
Associations of Pittsburgh Sleep Quality Index (PSQI) with outcome measures (univariate regression)
- Significant associations between PSQI and DAS28-CRP, tender points, visual analogue scale (VAS) patient global and pain, PsA Impact of Disease fatigue, Health Assessment Questionnaire (HAQ) and painDETECT score
- P < 0.001
Independent associations with PSQI (multivariate regression)
- VAS patient global, VAS pain and tender points independently associated with PSQI
Effect of treatment on PSQI in PsA (mixed-effect model)
- No effect of treatment
Original publication
Increased prevalence of sleep disturbance in psoriatic arthritis is associated with inflammatory and non-inflammatory measures. Scand J Rheumatol. Published 18 March 2022. doi:10.
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