Spondyloarthritis & psoriatic arthritis
Confounders contributing to explain the association between sex and disease impact in patients with recent-onset psoriatic arthritis
Authors' conclusion
The association between female sex and greater disease impact could be explained by the influence of other variables, specifically higher HAQ score, greater intensity of pain, differences in the level of physical activity and in the joint pattern at diagnosis (lower frequency of the spondylitis pattern in women).
Study context
- Population
- Patients aged ≥18 years fulfilling the CASPAR criteria with recent-onset PsA (<2 years since symptom onset)418 observations
- Exposure
- Female vs male sex
- Outcome
- Association between sex and disease impact (PsAID ≥4), adjusted for confounders
Methodological detailsmulticentre, observational, 2-year follow-up, regular annual visits, multivariate logistic regression
- Multicentre
- Observational
- 2-year follow-up, regular annual visits
- Multivariate logistic regression
Main finding
As reported in the abstract
PsAID ≥4, adjusted for HAQ, global pain, physical activity level and joint pattern at diagnosis
- No statistically significant association between female sex and PsAID ≥4 after adjustment
- Confounders identified: HAQ, global pain, level of physical activity, joint pattern at diagnosis
Observational data: associations, not effects.
Original publication
Confounders contributing to explain the association between sex and disease impact in patients with recent-onset psoriatic arthritis. Clin Exp Rheumatol. Published 3 March 2022. doi:10.
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