Spondyloarthritis & psoriatic arthritis
High prevalence of radiographic erosions in early, untreated psoriatic arthritis (PsA): results from the SpARRO cohort
Authors' conclusion
Erosions were seen in a quarter of patients with newly diagnosed, untreated PsA with a declining trend around the 8-month symptom duration cut-off. High levels of agreement between CR and US were seen with CR detecting more erosions.
Study context
- Population
- Newly diagnosed, treatment-naïve PsA patients fulfilling ClASsification for Psoriatic Arthritis (CASPAR) criteria, ≤5 years symptom duration, Leeds Spondyloarthropathy Register for Research and Observation4,655 hand and feet joints
- Participants
- 122 participants
- Exposure
- Conventional radiography (CR) vs ultrasound (US) for detection of bone erosions
- Outcome
- Prevalence and distribution of bone erosions on CR
Methodological detailsinception cohort (SpARRO), CR and US examination of hands and feet
- Inception cohort (SpARRO)
- CR and US examination of hands and feet
Main finding
As reported in the abstract
Patients with CR erosions
CR
24.6%
30 events
Observational data: associations, not effects.
Further findings
Number of erosions (joint level)
Erosions at 5th MTP joint (most affected site)
- Number of erosions (joint level): CR: 63/4,655 joints; US: 34/3,270 joints
- Erosions at 5th metatarsophalangeal (MTP) joint (most affected site): CR: 11/211; US: 15/210
CR erosion prevalence by symptom duration
- Below 8 months of symptoms (lowest prevalence)
- 17.5%
- >24 months of symptoms
- 24.3%
Distribution of erosions
- CR erosions more evenly distributed; on US three-quarters of erosions in wrists, second metacarpophalangeal (MCP) and fifth MTP joints
Agreement between CR and US (prevalence-adjusted bias-adjusted kappa)
- Most joints almost perfect agreement, kappa range
- 0.91 to 1
Original publication
High prevalence of radiographic erosions in early, untreated PsA: results from the SpARRO cohort. RMD Open. Published 5 April 2024. doi:10.
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