Spondyloarthritis & psoriatic arthritis

Assessment of enthesopathy in conventional pelvis radiography: Another tool for spondyloarthritis diagnosis beyond sacroiliitis

Semin Arthritis RheumPublished Diagnostic accuracy study

Authors' conclusion

The assessment of pelvic enthesis using the REI on pelvic radiography may be useful for SpA diagnosis. Total REI, ZIII, and ZI had the highest accuracy and almost perfect reliability.

Study context

Population
Spondylarthritis (SpA) patients and controls with chronic lumbar pain without SpA
Participants
161 patients
Comparison
Radiographic enthesis index (REI) on pelvic X-ray vs sacroiliitis on X-ray for SpA diagnosis
  • SpAn = 111
  • Controlsn = 50reference
Outcome
Association of pelvic enthesis involvement on pelvic X-ray (REI) with SpA diagnosis; reliability and accuracy of the REI
Methodological detailsblinded observers, case-control (SpA vs chronic lumbar pain controls), Three blinded observers assessed each pelvic radiograph three times; weighted kappa adjusted with Gwet's agreement coefficient
  • Blinded observers
  • Case-control (SpA vs chronic lumbar pain controls)
  • Three blinded observers assessed each pelvic radiograph three times; weighted kappa adjusted with Gwet's agreement coefficient

Performance

As reported in the abstract

Sensitivity for SpA diagnosis
Test or modelValueSensitivity
REI82 %82 %
Sacroiliitis on X-ray38.7 %38.7 %

Value

REI82 %
Sacroiliitis on X-ray38.7 %

Sensitivity

REI82 %
Sacroiliitis on X-ray38.7 %

Further findings

REI Grades 1 to 3 in ZI (iliopubic ramus)

Grade 1 SpA 8.1 %

Grade 2 SpA 14.4 %

Grade 3 SpA 19.8 %

ZII (pubic symphysis) unaffected

OutcomeSpAControls
REI Grades 2 and 3 in ZIII (ischiopubic ramus)36.7 % and 25.7 %6 %
Grade 236.7 %— not stated in the abstract
Grade 325.7 %— not stated in the abstract

— not stated in the abstract

REI-positive among SpA patients without sacroiliitis on X-ray
75 %

Original publication

Assessment of enthesopathy in conventional pelvis radiography: Another tool for spondyloarthritis diagnosis beyond sacroiliitis. Semin Arthritis Rheum. Published 4 April 2024. doi:10.1016/j.semarthrit.2024.152435

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