Spondyloarthritis & psoriatic arthritis
Depression and anxiety in a real-world psoriatic arthritis longitudinal study: should we focus more on patients' perception?
Authors' conclusion
In PsA, depression and anxiety are associated with worse PROs, including QoL. Subjective parameters of disease activity parallel course of depression.
Study context
- Population
- Psoriatic arthritis (PsA) patients attending two outpatient rheumatology clinics (January 2019-June 2021)
- Participants
- 128 patients
- Outcome
- Depression (HADS-Depression) and anxiety (HADS-Anxiety), cut-off scores ≥11, and their course
Methodological detailstwo outpatient rheumatology clinics, consecutive enrolment, two sequential visits
- Two outpatient rheumatology clinics
- Consecutive enrolment
- Two sequential visits
Main finding
As reported in the abstract
first visit
Prevalence of depression
19.5%
Prevalence of anxiety
21.1%
Observational data: associations, not effects.
Further findings
Factors associated with depression
| OR (95% CI) | P value | ||
|---|---|---|---|
| EQ-5D | 1.70 (1.02–2.59) | P = 0.019 | |
| 0.20.5125Odds ratio (log scale) |
Factors associated with anxiety
| OR (95% CI) | P value | ||
|---|---|---|---|
| EQ-5D | 1.81 (1.20–2.72) | P = 0.005 | |
| Nocebo-behaviour | 1.19 (1.01–1.40) | P = 0.04 | |
| Current corticosteroid use | 6.95 (1.75–27.59) | P = 0.006 | |
| 0.050.21520Odds ratio (log scale) |
Improvement in hospital anxiety and depression scale (HADS) scores at second visit · second visit (mean±SD: 10±6 months)
- HADS-Depression score improved
- 40.9%
- HADS-Anxiety score improved
- 41.9%
Correlation of HADS-Depression score change with changes in disease activity parameters
- Tender joint count, r
- 0.204 (p=0.049)
- PtG, r
- 0.236 (p=0.023)
- Patient pain assessment, r
- 0.266 (p=0.01)
- No correlation with objective parameters (swollen joint count, ESR, CRP)
- No associations found for HADS-Anxiety score change
Original publication
Depression and anxiety in a real-world psoriatic arthritis longitudinal study: should we focus more on patients' perception? Clin Exp Rheumatol. Published 28 February 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →