Lupus & antiphospholipid syndrome
Increased expression of TRIM69 in peripheral blood from systemic lupus erythematosus and its clinical significance
Authors' conclusion
The study suggested that the elevated TRIM69 may play a role in SLE pathogenesis and predictive model based on serum TRIM69 levels, HGB, and NLR act as bioindicator for forecast and progression of diseases.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE), healthy controls and patients with rheumatoid arthritis (RA); TRIM69 mRNA in whole blood (RT-qPCR) and serum TRIM69 (ELISA)
- Participants
- 72 / 62 / 65
- Comparison
- SLE vs healthy controls (HC) and RA
- SLEn = 72
- HCn = 62reference
- RAn = 65reference
- Outcome
- Predictive model (serum TRIM69, haemoglobin (HGB), neutrophil-to-lymphocyte ratio (NLR)) distinguishing SLE from HC
Methodological detailscase-control, 5-fold cross-validation, independent validation cohort
- Case-control
- 5-fold cross-validation
- Independent validation cohort
Performance
As reported in the abstract
| Test or model | AUC | Sensitivity | Specificity | Overall accuracy | Kappa |
|---|---|---|---|---|---|
| Training | 0.941 | 93.55% | 81.94% | — not stated in the abstract | — not stated in the abstract |
| Cross-validation | — not stated in the abstract | — not stated in the abstract | — not stated in the abstract | 86.55% | 0.731 |
| Independent validation | 0.931 | 87.50% | 87.50% | — not stated in the abstract | — not stated in the abstract |
AUC
Training0.941
Cross-validation— not stated in the abstract
Independent validation0.931
Sensitivity
Training93.55%
Cross-validation— not stated in the abstract
Independent validation87.50%
Specificity
Training81.94%
Cross-validation— not stated in the abstract
Independent validation87.50%
Overall accuracy
Training— not stated in the abstract
Cross-validation86.55%
Independent validation— not stated in the abstract
Kappa
Training— not stated in the abstract
Cross-validation0.731
Independent validation— not stated in the abstract
— not stated in the abstract
Further findings
TRIM69 expression
- Significantly elevated in SLE vs HC and RA; strongly correlated with clinical features
Serum TRIM69 alone
- Showed discriminatory ability for SLE in ROC analysis
Model: SLE vs RA and HC combined
- AUC
- 0.805
- Model correlated with SLE disease activity
Original publication
Increased expression of TRIM69 in peripheral blood from systemic lupus erythematosus and its clinical significance. Clin Exp Rheumatol. Published 1 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →