Lupus & antiphospholipid syndrome
Automated whole-blood detection of IFI27 and OAS1 mRNA for distinguishing active systemic lupus erythematosus
Authors' conclusion
This automated whole-blood assay offers a rapid and reliable method for ISGs detection. IFI27 and OAS1 combined with C3, serve as sensitive biomarkers for monitoring of active SLE in routine care.
Study context
- Population
- Patients with SLE
- Participants
- 102 patients
- Comparison
- Active SLE vs inactive SLE
- Activen = 38
- Inactiven = 64reference
- Outcome
- Whole-blood mRNA levels of five interferon-stimulated genes (ISGs) (IFI27, OAS1, IFI44L, LY6E, IFIT1) and their performance in distinguishing active SLE
Methodological detailsautomated multiplex RT-qPCR, ROC analysis, backward stepwise logistic regression
- Automated multiplex RT-qPCR
- ROC analysis
- Backward stepwise logistic regression
Performance
As reported in the abstract
ISG expression, active vs inactive SLE
ISG expression significantly elevated in active SLE (fold)
2.9-17.3
Further findings
IFI27 in clinically inactive patients
- Elevated IFI27 associated with persistent leukopoenia
Original publication
Automated whole-blood detection of IFI27 and OAS1 mRNA for distinguishing active systemic lupus erythematosus. Rheumatology (Oxford). Published 4 April 2026. doi:10.
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