Lupus & antiphospholipid syndrome
Comparison of Evans syndrome and isolated autoimmune cytopenias in SLE: a retrospective study
Main finding · Number of severe SLE flares per patientResult — go to the resultIncidence rate ratio 3.03 95% CI 1.50–6.41Authors' conclusion
In patients with SLE, ES is associated with an increased risk of severe flares than isolated autoimmune cytopenia.
Study context
- Population
- Patients with SLE presenting with immune thrombocytopenia (ITP), autoimmune haemolytic anaemia (AIHA) or Evans syndrome (ES) of clinical significance (requiring therapeutic intervention per EULAR guidelines or clinician discretion)
- Participants
- 95 patients
- Exposure
- SLE with ES vs SLE with isolated autoimmune cytopenia
- ESn = 30
- ITPn = 43reference
- AIHAn = 22reference
- Outcome
- Severe SLE flares (SLE Disease Activity Index ≥10)
Methodological detailsmulticentre, inverse probability of treatment weighting
- Multicentre
- Inverse probability of treatment weighting
Main finding
Number of severe SLE flares per patient
Incidence rate ratio
3.03
95% CI 1.50–6.41
By group
ES
1.3
ITP
0.4
AIHA
0.4
ESvs ITP or AIHA
IRR 3.03 (95% CI 1.50–6.41)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | ES | ITP | P value |
|---|---|---|---|
| Renal involvement · last follow-upES vs ITP | 36.7% | 9.3% | P = 0.007 |
| Neurological involvement · last follow-upES vs ITP | 36.7% | 11.6% | P = 0.019 |
Safety
| Outcome | ES | ITP | P value |
|---|---|---|---|
| Severe infectionsES vs ITP | 47% | 23% | P = 0.045 |
| Mean number of severe infections per patientES vs ITP | 1.2 | 0.5 | P = 0.04 |
Original publication
Comparison of Evans syndrome and isolated autoimmune cytopenias in SLE: a retrospective study. Lupus Sci Med. Published 1 April 2026. doi:10.
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