Sjögren's disease & overlap diseases
Inclusion-body myositis associated with Sjögren’s disease: clinical characteristics and comparison with other Sjögren-associated myositis
Authors' conclusion
IBM can occur in SjD patients, with muscle features reminiscent of classic sporadic IBM characteristics, but mostly affecting women.
Study context
- Population
- Patients meeting ACR/EULAR criteria for Sjögren's disease (SjD) and for inflammatory myopathies (IM), 13 French centres
- Participants
- 22 vs 50
- Exposure
- SjD-IBM vs SjD-other IM
- SjD-IBMn = 22
- SjD-other IMn = 50reference
- Outcome
- Characteristics of SjD-IBM
Methodological detailsmulticentre (13 French centres), Retrospective recruitment
- Multicentre (13 French centres)
- Retrospective recruitment
Main finding
As reported in the abstract
| Group | Value | Age at SjD diagnosis | Age at first inclusion-body myositis (IBM) symptoms | Females | ESSDAI at SjD diagnosis | Progressive symptom onset | Asymmetrical involvement | Distal involvement | Dysphagia | CPK | CRP | Immunosuppressants reported efficient |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SjD-IBM | median 54 (IQR 38.5–64) years | 54 [38.5; 64] years | 62 [46.5; 70] years | 86% | 5.5 [1; 7.8] | 59% | 27% | 32% | 41% | 386.5 [221.8; 670.5] UI/l | 3.0 [3; 8.5] mg/l | 55% |
SjD-IBM
Valuemedian 54 (IQR 38.5–64) years
Age at SjD diagnosis54 [38.5; 64] years
Age at first inclusion-body myositis (IBM) symptoms62 [46.5; 70] years
Females86%
ESSDAI at SjD diagnosis5.5 [1; 7.8]
Progressive symptom onset59%
Asymmetrical involvement27%
Distal involvement32%
Dysphagia41%
CPK386.5 [221.8; 670.5] UI/l
CRP3.0 [3; 8.5] mg/l
Immunosuppressants reported efficient55%
Observational data: associations, not effects.
Further findings
| Outcome | SjD-other IM |
|---|---|
| SjD-other IM vs SjD-IBMValue is ESSDAI | 11 (IQR 3–30) |
| ESSDAI | 11 [3; 30] |
| Delay SjD diagnosis to myositis onset | 0 [−0.5; 26] |
| CPK >1000 UI/l | 36% |
SjD-other IM vs SjD-IBM
- SjD-other IM significantly younger, more frequent additional extra-glandular disease, higher ESSDAI, shorter delay, more frequent CPK >1000 UI/l, less frequent classic IBM features
Original publication
Inclusion-body myositis associated with Sjögren’s disease: clinical characteristics and comparison with other Sjögren-associated myositis. Rheumatology (Oxford). Published 1 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →